Gunbei: It's a good question, but fortunately you almost never need to compromise. The flatest response is with subs placed on opposite walls at the midpoint. Now if it were for music and it was a high crossover point (say 80Hz or higher) I would move them back closer to the main speakers but symetrical, and relatively close to the wall (within 1/8 of a wavelength of the crossover point). In a non-symetrical room, this may not be the case. Here's an even more interesting phenomenon (purely hypothetical--because I don't know anyone that's actually done a room like this). If you use 4 subwoofers and place them 1/4 of the crossover wavelength from the corners of the room you get a nearly flat response throughout the room--no peaks or nulls (obviously there would be minor ripples due to furniture and other items in the room in practice, but in theory it's a flat response). In this last example it does assume a mono signal. In your case, you would not need a mono signal because most of the lower bass notes are mono. If the crossover point is high--then that might not be true and you could run into some difficulties, but no more than having 2 main channel speakers that carry the bass information independently. So, I guess I don't really see any significant downside to stereo subs--I hope I've explained that adequately.