Hi Stbhorn. Two months ago I upgraded a menagerie of cables that included Cardas, Harmonic Tech, Kimber and Analysis Plus to an all Virtual Dynamics cryo'd Audition Package. I was using the Analysis Plus BiOval 9 for almost a year and sold them three weeks before the Audition Package arrived so I couldn't do a direct comparison. When the Virtual Dynamics did arrive, the first thing I did was to replace only the speaker cables with my old interconnects still in place. From distant aural memory my impressions were that the Virtual Dynamics were smoother and more open.
In my system I feel the most improvement came when I initially replaced my Absolute Power Cords with three Virtual Dynamics Power 2 PCs. The interconnects and speaker cables were definitely an improvement, but not to the same degree as the power cord upgrade, which was a gigantic step up.
Just as Rpw reports one of the most noticeable differences was the increase in volume, but that was going from the Absolutes to the Power 2s. I didn't notice as a much a gain when inserting the cryo'd Auditions, but that doesn't rule out the possibility of me upgrading to cryo'd Reference, Signature or Nites in the future.
Good luck!
