Overall, the room is not pressurized by your speaker. When the cone moves forward, there is a brief increase in pressure, but when it moves backward, there is a corresponding reduction in overall pressure. A wave has a portion that has a higher pressure and a corresponding part that has lower pressure than the ambient pressure of the room. What you are reducing by opening a door or window is the acoustic energy in the room (less is bouncing around and more is escaping). This will change the sound, and whether that change is good or bad depends on the particular room and system and the volume level the system is playing at. If you are playing at such a high level that the room is overloading, backing off the volume will do more than opening a door. In any case, just listen to the result; theory will not accurately predict the result.
I was present when an industry expert was helping a friend set up one of his listening rooms. He open and closed doors, moved sound absorption and scattering panels around and listened to the results rather than following any sort of formula/theory. This room sounded better when the panels at the first reflection points on the side walls were removed, for example. As for open doors, this room sounded better with the door to the room closed, but with a door to a closet in the room opened (the closet acted as a bass trap).

