Speaker shootout question -- do you position the same or differently, depending?

In my experience different speakers with behave quite differently depending on placement to boundaries and distance to listing position (reflection points, nodes, etc.)  The position of the drivers in the cabinet will give a wildly different presentation, as will the width and depth of the cabinets. 

If you don't have a symmetrical space -5, if  you don't have the ability to move the speakers around -3, add a great amp to this not optimal set +2, new expensive cables +1, etc. Obviously this isn't a scientific rating but without the first two, the (everything matters) approach with be skewed as well. Amps and cables matter more if you have the first two.

Do the best you can and have fun +10. 

Just want to add that if people are overwhelmed with a large room, it's sometimes easier (and maybe even preferable in sound quality) to section the space and be closer to the speakers. I've heard many setups where I preferred my at home closer, more direct interaction with my speakers to larger, even well treated spaces. Lots can happen for better or worse in that space between your speakers and your ears. There's nothing wrong with being a bit closer if the dispersion works. I've yet to see an 18X40 mixing room.