The PL amps are designed to safely accomodate this. However, Kevin at Upscale can probably give you the upside/downside of operating the amp in this fashion. I think that I've used every outpube tube out there in my PL 7s and there's a fair bit of character shift when you change the output tubes. I've pretty much settled on KT 66s for most apps.
Good Luck
Marty
Good Luck
Marty