Likely culprit for harshness at higher volumes?

Hi,

I'm a newbie to higher end audio. I have a very modest system:
1) Pre-amp: Anthem AVM2
2) Amp: Adcom GFA-5400
3) Source: Sony CDP-X111ES CD player
4) Speakers: KEF C75
5) Toslink between source and pre-amp; cheap RCA cables from pre-amp to amp; 16 or 18 gauge speaker wire (Radio Shack?)

Room setup (10-ish feet x 20-ish feet rectangle):
1) 2 foot deep cabinets along one wall (20-ish foot)
2) Components stacked on top of small end table against rear wall (10 foot); centered between cabinets and opposite wall.
3) Speakers slightly in front of end table and about 2 feet from side walls and 4 feet from rear wall

Sounds good at about -45 to -25db; but higher frequencies get harsh at higher than -25db.

Appreciate your thoughts.