3 way vs. 2 way

I currently have Mirage M5si bi polar speakers, I believe these have two tweeters and two 6inch drivers. For my room size I want to go to a conventional speaker. I would also like to give a high end store in my area the business as the owner is a friend. He carries Totem and B&W. I notice may of the Totems have only a tweeter and a driver. Can I get as good sound out of smoething like that as compared to a speaker with 3 or 4 in the cabinet?