My experience has been that, ideally, 3 matching across the front is best. That however needs to be quantified in the context of the system/room/setup. Basically, a lot of full range speakers, or mini's for that matter, aren't really all that capable of producing solid, dynamic, coherent, and focused sound, period!...inlarge, they make ineffective movie speakers IMO. And I've sold alot of audoiphile speakers over the years.
There is something to be said for a good speaker for movies vs. just for music. Dual midrange/bass woofers, or others.
Having reinforced midrange, bass and treble drivers, either using horns, or dual/multiple mid/bass drivers, multiple tweeters, large pannels, and/or high efficiency designs in general(like active's, horns, multiple driver array's, etc) often make for a more solid home theater speaker. This is especially true in the critical center channel, where a lot of action is mixed!
Basically, there are a number of designs that are just to week, laid back, uninvolving, "open", and polite sounding do to true justice to what I call "the hard stuff"!
But, there are considerations.
If you have to use a traditional designed stereo speaker for HT dubties, they most always work much better not only crossed over as "small", but used in a smaller setting, or where you sit acoustically "closer" to the speakers...thus you hear more dirrect sound vs. reflected sound from the room boundaries. This tends to "reinforce" the sound from the speakers more for your ears.
Still, all things equal, I'd say it depends greatly on the design of the speakers.
Also, since most typical full range consumer home audio speakers are passive, and low on efficiency/sensitivity, it often makes for better control and powerhandling when you cross over the speakers as "small", and dictate the more demanding dynamic bass info for an "active" speaker, like a powered subwoofer.
Now I have head some full rangers that do pretty darn well as "full range", and as center channels. Big Dunlavy's, Avantgard horns, PSB Stratus Gold's, Infinity Prelude MTS's,NHT VT3's(powered subs) and other powered models, maybe a wilson WATT PUPPY, and other larger, higher efficiency designs.
Ok, this is all my experience, and you can really do what you want. I just think some designs don't do it so well.