@newton_john thanks for the book reference; my library has it and I’m going to take a look.
@stuartk I’m not talking about utilizing substances in precise doses, only trying small amounts to see if one’s perceptions alter and give them a new insight into how their system sounds. It’s not more complicated than that, but too many here have taken ASC and assumed that I mean becoming sh*t-faced. That’s not it at all. It’s about stirring things up a little bit and taking another look.
@sns "Our only reference for timbre is acoustic instruments played without sound reinforcement." Not sure I agree. I’ve heard Stratocasters played through amps, live; wouldn’t that be a timbre that could serve as a reinforcement? Indeed, any electrified instrument that is recorded via a mic would then be a reference for the later-amplified sound coming out of a stereo. But, perhaps, the change in timbre is just not as critical – perhaps that’s the point, namely that there would not be "gross timbre inaccuracies" which would induce stress.
Regarding LSD and the visualization of space, this is an interesting example insofar as it indicates another possibility for my suggestion. Not so much that one alters perception while they’re listening to audio, but that they take note of how acoustic space sounds at another time while under an ASC. Then, as you did, they can consider that angle of view later on, when they are listening to music. We gain new perspectives with ASC’s and if they can be somehow incorporated into our way of understanding things, they become resources to break out of routine judgments.

