What I have noticed is that my old Thiel speakers which had the mineral front baffles were totally inert on that face but vibrations could be felt on the sides and back of the speaker cabinets. That tells me the speakers were transmitting vibrations from the cabinet bottom through the spikes to the floor and some amount of vibration reflecting back into the cabinets. So the Gaias which both dampen and isolate seem to me to improve the sound of the speakers by both isolating the speakers from the floor and damping reflections that would otherwise go back into the cabinets. The Wilson speakers are remarkably inert on every surface. Totally dead no matter the loudness they are playing. And yet they still transmit vibrations to the floor through their spikes as well. Perhaps the energy must go out of the cabinets somewhere. I find the Gaia Titans remarkably effective on my Wilson speakers. I would like to hear them with the new Wilson isolation spikes but my curiosity has limits. I have no doubt the Wilson isolation spikes would be an improvement. Their material development knowledge is remarkable when considering they can build an entirely inert speaker cabinet.
I think any speaker will benefit by isolation from the floor but the tonal qualities of the speaker might be altered, as I found with my Thiels and so some amount of dampening (damping) might be needed to go along with the isolation. That’s likely something to be solved on a case by case basis. Some of us engineer types are able to come up with some good homemade solutions, but I have to give credit to the entrepreneurs who develop a product for the market that has to work 90% of the time on a wide range of applications- sometimes great and sometimes not. Some people like hang gliding. Some of us like the security of an enclosed cabin.