Which worse- long I/C of speaker run

Musical Fidelity had their new M250 power block amplifiers. Their pitch goes that the amp is close to the load (speaker) so to "give the amplifier excellent damping".

But this will require long 2-12 foot runs of I/C. So which is worse? Long runs of speaker cable or interconects? Will the delicate low level signal be losing information with a long I/C.

I would think the preamp would require full balanced outputs (preferably all the way through the preamp - Mike Creek was displaying such a preamp) to prevent signal loss.
Any thoughts? Thanks