Speaker suggestions for less than ideal accoustics

I live in a lovely timber frame home that works well for our lifestyle but presents challenges when trying to create a good audio listening environment. My great room has a wall of windows, tile floors (radiant heat), a large stone fireplace,28' ceiling peak, open to a loft area and open to the kitchen/dining area. The space is approx 1000 sq ft. I have listened in stores to some nice speakers (JM labs 816s, Def Tech 7004, Paradigm studio 100s, PSB T55,) but I know none of them will sound the same in my great room. Anyone ever faced this challenge and know if certain qualities in speaker designs lend themselves to this? I have learned a lot from this forum and wish there were more places to hear some of the equipment mentioned. BTW,this is for music listening only. Home theatre will have its own dedicated room in the basement where things can be built to suit