@markmuse If I were in your situation, I would first talk to Duke at Audiokinesis and get a set of his Swarm subs. They would allow you to have proper bass anywhere in the room. The Swarm is 4 subs so as to break up standing waves that otherwise cause bass nulls to appear in the room, often at the listening position. They also prevent too much bass elsewhere in the room.
That would free you up to use a smaller speaker since the Swarms are good up to about 50-60Hz. That would open up a lot of possibilities for easy to drive speakers; if they are easy to drive the amps don't have to be as powerful, and often the smaller amps are the better sounding ones.