Yeah thats a good combo. The Gryphon Diablo is one of the best integrated amps out there. The Dynaudio C4s have a great bass response with really nice mids. I heard it at the 2002 stereophile show.
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Yes. The Gyphon Diablo has sufficent power handling ability to drive the C4's.
As the Gryphon Diablo is neutral in character the resulting sound will be determined by the rest of your system and of course the room interface.
No to the Sapphire. I found the resulting sound too edgy. Better to stick to the Confidence range but there are many good speaker choices out there.