There's a really good thread in AudioCircle that deals w/ this topic. I really like my friend Dejan Veselinovic's (AKA the Serbian Hope) answer, as it is original and thoughtful. He says RCA usually sounds beter than balanced if the ground is filtered. My current setup happens to use RCA interconnects and a 3KW, 220V/110V ONEAC islolation transformer/filter that has a patented "Virtual Ground" feature that isolates the building's ground from the transformer's. My system is real quiet--spooky quiet.
http://audiocircle.com/circles/viewtopic.php?t=8355
http://audiocircle.com/circles/viewtopic.php?t=8355