Certainly, long runs, if equipment offers, use XLR to protect from the added potential of problem(s). But, even a long run at home, really not the same need as a swarm of this and that in commercial setups.
Short runs, home audio system, why?
One clear advantage is the snap in locking connector.
For stable matched secure contacts for L and R, I changed all my interconnects to locking rca connectors, and use XLR/RCA from my Sony CD player's XLR out, just to compare. I cannot hear any difference between it's XLR out or it's RCA out.