Room interaction is much greater for panels due to the forward and rear radiation. They are also more challenged to create the higher SPL's needed in large spaces..
Your best bet would be a narrowly focused Appolito type design such as a Dunlavy SC V or similar...these will limit the room interaction somewhat at the expense of a smaller sweetspot.
However, I would add that in general a wide dispersion speaker tends to sound the most "natural". Although a speaker that also radiates to the rear can actually over excite the room (this can simulate typical reverberant concert halls, school halls, churches and typical venues where you get a lot of ambient reflected energy - so classical concert hall goers will often favor panels foor the exciting ambient sound field. Listeners who crave accuracy tend to favour near-fields or Dunlavy designs)
Your best bet would be a narrowly focused Appolito type design such as a Dunlavy SC V or similar...these will limit the room interaction somewhat at the expense of a smaller sweetspot.
However, I would add that in general a wide dispersion speaker tends to sound the most "natural". Although a speaker that also radiates to the rear can actually over excite the room (this can simulate typical reverberant concert halls, school halls, churches and typical venues where you get a lot of ambient reflected energy - so classical concert hall goers will often favor panels foor the exciting ambient sound field. Listeners who crave accuracy tend to favour near-fields or Dunlavy designs)