If your amp contains the super balanced topology it will benifit from running fully balanced. There is a new circuit recently released into the VTL 6.5 that was not included until a recent release. Make sure you get the latest version. It incorporates updates that have been introduced into the VTL 7.5 mk II. They didn't rebadge it though. Also the updates increase dynamics while maintaining transparency. It is a worthwhile upgrade. If you like the VTL sound then stay w. the VTL preamp. I honestly believe there is a strong synergy staying with a brand to some extent.