Would you sit backwards listening to live music? Hell NO!
In your room you can easily change your layout so you are sitting dead center of a pair of speakers, getting great sound as well as amazing imaging, hard to do in an office. I changed mine, 1st time ever having great Imaging in my office, dead center on my keyboard/monitor/chair. YouTube Videos, sound centers/images on the monitor with L/R side effects as recorded/engineered.
You can put a row of stuff including speakers on the front wall, working around the existing window.
Pull your desk back to leave a small aisle in front of your desk (you have plenty of depth).
My room is smaller, so I put 12" bookcases with 14" top, thus I have a vertical TT and Vertical Reel to Reel, as well as Little Luxman Integrated Tube Amp. You could easily put a cabinet with a top big enough for both speakers and a Horizontal Turntable now or later.
Use your existing desk, or for more surface, you could make an L shaped desk, keep keyboard/monitor centered on the speakers in the front, add side surface on the right side, side aisle to the front wall on the left closet side
mine is Left L, yours would be Right L. My front is simply a countertop on a file cabinet one end (keyboard shelf to keep desk surface open)., and side counter with support on the wall side.
Note: pick efficient speakers to reduce power needed, which reduces money/size/heat while increasing placement options, and allows a small tube amp (small amount of heat) if desired. In my case, I do very well with 10wpc tube amp.
Lower volumes in office, no need for very high efficiency, just avoid low sensitivity models.
Oh yeah: Pick speakers with NO REAR Port.
Note: you want the tweeters at your seated ear height, thus my bookshelf speakers are horizontal. Middle Image shows my current Restored AR-2ax speakers (white linen), other photos show prior Wharfedale 225’s (black fabric) (I used a small sub with the Wharfedales, just so they did not seem small; not needed with AR-2ax’s 10" woofer
more photos in my Virtual Systems on this site (just click anyone's name, their virtual systems, if they have made any, are shown below their name).
