Amplifier Weight. A Factor?

Absolutely! I sold a KR Audio Antares even though I liked the way it sounded because it weighed 90 lbs and I was sick of lifting/moving it! I went with a succession of nice tube amps in the 30-50 lb range. The thing about heavy amps, tube amps especially, is they're not just heavy but awkward because of how the weight is distributed. SS amps often have handles but tube amps almost never do.

Everything else being equal (and in reality it never is) the reason that large amps are very heavy is they have very heavy transformers which you really need to get high quality power and things like subterranian bass. If you can settle for less power, and don't need really deep bass, you're less likely to get a hernia. I have both heavy monos and a lite 35 watter and for the power I need the only real difference tonally is the impact in the bass below 30hz. FWIW YMMV.

Although you need big and heavy transformer to have true high power output, it is difficult to handle. I sold my krell 700 cx because of that and go for Nagra VPA.

my favorite amplifier is the conrad johnson mv 125. another amp i liked a lot was the quicksilver ms 190. both amps weigh over 80 pounds.

its a sample not a universe.

if you like the amp weight should not matter.

better to buy one heavy amp than buy and sell 5 lighter weighing amp.

Efficient speakers enable you to pursue high performance amplification without heavy weight. A side benefit lies in being able to buy high quality low power for the price of medium quality high power. My main amp weighs 12 lbs. and my sub amp weighs about 45 lbs.They are state of the art products and I have a little over $2K total in them.
Yes, amplifier weight affected my choice of both amps and speakers.