best used amp pre-amp combo for a grand

I would go for a nice integrated.. for the money..
Try a Musical fidelity A300.. very nice piece supposed class a design and true dual mono.. Great binding posts and very musical with tons of bottom end... the klipschs will sing. The Krell 300i is a little pricer but still nice..
If i had to pick separates.. go for a b and k Pro 10 mc for about 300.00 and spend the rest on an aragon 8002 dual mono... that is a killer combination.. Try to get an 8002 with xlr.. the pro 10 has xlr outs and is a sweet preamp with a passive mode and external power supply.. great piece..

"I do want to be able to run speakers in 4 locations."

Better check Audio by Van Alstine's integrated amp. The professor knows what he's doing...and his amps are designed for long speaker runs. I heard his stuff at the Chicago Audio Society last November--truly outstanding, affordable high end gear.

BTW, I heard that Musical Fidelity A300 in Ann Arbor last month and sounded AWFUL. Read my post "Voodoo in Ann Arbor."

Go to Bottlehead.com and look at the Foreplay/ Paramour combination.

For an amplifier,look into Hafler. They are musical and reliable, unlike much of the high end junk out there that has a high failure rate. The preamp? Acurus.

Try picking up an Acurus amp & preamp combo. Mondial who was bought out by Klipsch had cleared out most of their stock as they were dropping this brand name.
They have a 5 channel 125X5 and a 200X5 that you may be able to get used for under 70.00??

I still see some of the amps for sale out on audioreview.com and many people have posted reviews out there as well.