Run length


Room layout dictates the sub is on the opposite wall. Not ready to run a wire across the floor. It would be 26 feet.

To skip the floor run I would have to go up and down inside the wall. That would add another 18 feet for a total of 44 feet.  Too long?  Will be using plain old 14AWG cord.
128x128ibmjunkman
Sorry I did not catch that your sub is not powered. Perhaps consider going to that type of sub?

ozzy
It will not hurt anything if it is powered but if it is a passive sub you will need much heavier wire for a 44 foot run.
Is this an RCA (signal wire) or are you taking the speaker output to the sub ?

If a signal wire, make sure your wire is very well shielded.  If a speaker output, you are ok.

In any case, you can also consider wireless:

https://www.martinlogan.com/en/product/swt1
Correction, I just realized that the Martin Logan transceiver is specific only to their own Dynamo subwoofers.

But you get the idea. There are quite a few very good quality devices out there for wireless transmission with negligible latency.