Use the HT bypass feature on the wyred integrated and you by-pass the built in pre-amp all together. You can use any pre-amp you wish with the amp section only to evaluate your problem.
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In my experience, many of Eva Cassidy's recordings are harsh sounding... even when I had a tube preamp going into OTL amps and electrostatic speakers. So maybe the Wyred is letting you hear how those recordings actually sound... It is a very revealing amp, though not a harsh sounding amp unless the recording is actually harsh.
Sorry - I should have mentioned I no longer have the STI-500 integrated. I currently am using my long time Belles Ref 150 Reference amp with my Bel Canto SEP-2 preamp. I just purchased a ST-250 power amp and will compare it this week with the Belles. Eva's "Over the Rainbow" was the song I was referring to, and it has never sounded harsh over my current amp setup.