Let me clarify; I'm talking about biasing the tubes.
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in my experience it depends on your setup (ie cables, tweeters,) ive owned amps which sounded great no problems, but did recently have a Jadis Orchestra Reference which made female vocals at high freqencies distort.
all in all, if it is easy to do, (ie biasing pots in handy places) do it....
ive owned amps which needed quite a bit more work than that and used my ear. you can also swap driver tubes from channel to channel
I wouldn't be so easy going about wrong bias. If the bias is too high, not only can you fry the tubes, you can also get a lot of distortion. If the bias is completely off, you may cause more damage than you like if the tube blows suddenly.
If the bias is too low, you will overwork the amp and will lack output.