Why High Plate Voltage in 2A3 AMP?

Most of the designs I have seen, the plate voltage is about 300-320. However, I have seen few others that have plate voltage as high as 395.

This exceed the tube specification.
What is the pro/con of high plate voltage. My thinking is that it will kill the tube sooner.
The important spec is the difference betwen the plate and cathode voltage, not from the plate to ground. Many designs use a cathode resistor to bias the tube which raises the voltage at the cathode. If the plate voltage was 2000V and the cathode was 1700V the tube would still only have 300V across it.
I see, thank you, Herman.
So is there any benefit of having high B+, resulting in high plate (to ground) voltage?
Plate voltage isnt' what will kill the tube per se, it's more about dissipation (watts). B+ shouldn't really be a comparison factor if shopping for amps, it's but one part of a large picture. the difference between 320 and 390 is not that large really.

Benefits: sometimes cathodes (filament voltage) are floated higher than typical ground potential, for reasons of noise rejection. This is done with a voltage divider. That might impact where the B+ needs to be in relation, depending on how the power supply is set up. many variables, hard to generalize.

As Ed said, there are many variables and very few absolutes.

There are basically 2 ways to bias a 2A3. Both require the grid to be more negative than the cathode, or to look at it the other way the cathode more positive than the grid.

One way is to hold the grid close to zero via a resistor or choke to ground, then put a fairly large resistor from the cathode to ground so you have a positive voltage on the cathode. This requires a larger B+ since the cathode resistor drop and the tube are in series. It also usually requires a high quality cap to bypass the cathode resistor.

The other common way is to use a small resistor from cathode to ground so it is close to zero and then apply a negative bias to the grid. This requires a lower B+ and eliminates the cathode bypass cap but adds another supply for the grid bias.

Both have their merits and both are commonly used.

Ed's point about floating filaments does not apply to directly heated triodes such as a 2A3 since the cathode and filament are the same element. That technique is sometimes used for input and driver tubes like a 12AX7 or 6SN7 which have an indirectly heated cathode where the cathode and filament are not the same element. If the difference of potential between the two gets too big it can be detrimental so the filament is sometimes biased via voltage divider to a potential that is close to the cathode.
Thank you, Ed and Herman.
Having graduated from building a couple of kits. I feel that I am ready to build one from scratch. Researching schematics, gathering parts, etc. Hence the question. It will be a while for me to understand your insight completely, however from this thread I have learned several useful things.
Another way to do bias is with batteries (e.g. rechargable lead-acid usually). The positive side goes to the filament/cathode, neg to ground, and the current passing through it to ground keeps the batteries recharged. Sometimes people throw an LED in there too to adjust current draw.

Scratch-building is the way to go, btw. ;-) Stop over to TubeDIY on AA sometime for some real fun discussion on that.

The reason you see 300B preamps and not 2A3 preamps, is that low voltage gain is considered optimum for a good preamp...?