Sound men start with the drums, getting a great-but-too-loud sound from the kit. Then they do the same with the bass. After that there's nowhere for the higher pitched instruments and vocals to exist. And it all sounds like crap.
My wife and I were once at a Los Lobos outdoors show and the sound was so bad we decided to go home. As we were walking away we hit a point where the sound was decent enough so we sat there and stayed for the rest of the concert. So it can be a relative thing.
The most painfully loud band I ever heard was the 13th Floor Elevators at the Safari Club in Baytown, Texas ca. 1968. This was long before big PA systems so I'm not sure how they managed to do it. Small room, I guess.