As said, it depends on the components involved. You can ask the manufacturer or just see what sounds better to you.
USB has the advantage of handling higher sample rates. SPDIF or AES3 are usually limited to 192 kHz. USB does much higher. (It doesn't matter to me, but it might to you.)
USB has the advantage of handling higher sample rates. SPDIF or AES3 are usually limited to 192 kHz. USB does much higher. (It doesn't matter to me, but it might to you.)