The biggest change I've ever heard with speaker cables, was when I double biwired my Vanderdteen. 2 sets of AQ Type 6's sounded much better than my $3800 Tara 2's.
Other than that, the best way to deal with cables is to properly match your components. Do that, and you won't want or need cables that make big differences.
Other than that, the best way to deal with cables is to properly match your components. Do that, and you won't want or need cables that make big differences.