I replaced a pair of Vandersteen 5 with the Legacy Focus SE. I have a larger room, 16x 22, and it is treated with bass traps/first reflection absorbers. I listen to mainly rock, electronic, indie, acoustic. I am driving the Focus with Pass labs INT-150.
I really enjoy these speaks. They are truly full range and integrated, no particular frequency range sounds displaced from the music. They image well despite the multiple drivers. I particularly like the way they reproduce stringed instruments like electric/acoustic guitar, maybe this is due in part to the ribbon midrange and tweeter? Drum kits are also realistic in scale through these speakers including the kick drum.
Cons? Took me about a week to get used to their imposing size, especially compared to the Vandersteen's. Although the Whispers are even larger, they are supposed to work well near room boundaries and may be better for your space. However, if the 20/20's are working for you, the SE should too.