Try it to determine if you hear a difference. That's more valuable than someone's opinion. Good luck.
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I have the same deal -- Raysonic CDP with XLR outs and Aesthetix Calypso feeding S/E-only monoblocks. I use the balanced connections (Raysonic/Calypso) and think it sounds better, but direct A/B comparisons are difcult because of the much higher output via the balanced connections. As Narrod notes, try it both ways and see. Dave
I've had mixed line systems too. SE sources feeding a balanced power train. No prob with (if needed, good adapters). I've also run the balanced amp as SE with adapters.... again... no prob.
For me, the XLR path is quieter. the added 3-6 db gain was inconsequential. The quieter, darker backdrop made more a diff.
Was it enough to keep me in the XLR camp? Nope. I'm all SE now. It's all on you, how you wish to proceedd. Electrically, it ain't gonna hurt mixing inputs. Sonically, if the proper cabling is used, I don't think the diffs will be great enough that I'd be making wholesale changes either.
In fact...a component is designed either balanced or single ended. If the other system is available in the unit, it is very usually a compromise. What I'm saying is that components can sound better either way. I am using Ayre components which sound WAY better running balanced than single ended. Find out which your component sounds the best and go with it.