A single run works fine with my Vandersteen 1C / NAD C370 combination.
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I've used single runs and biwired runs in the past. On certain passages of music I thought the T14 portrayed some really nice musical cues, but I could never find a combination where they worked for me.
I think a lot of this had to do with my associated equipment which was the solid state Simaudio Moon I-5 integrated at the time. The speakers I used the T14 with were Sonus Faber Concertinos and ProAc Tablette 50 Signatures. I can definitely see the DH Labs speaker cable working with Vandies and PSB Golds, because of their fuller presentation, and for the price I think they're very good. Good luck.