Yes, they make a big difference, and yes, you need to experiment. I've had the best results with my CD player by supporting it on a maple cutting board with Aurios 1.2s beneath, used with their matching 7/16" tungsten carbide balls (the 1.2s are richer sounding than the 1.1s, and less bass heavy and clearer than the Pros). Aurios are relatively expensive, but they're worth trying, particularly under CD or DVD players-- they make as much difference as a good cable or component change.