Using 2 spades on 1 amp post

If I had 2 seperate pairs of speaker cables where I loved the bass on one and the highs on the other , is their any drawback to attaching 2 spades on {each post } to the back of my Classe Amp ? Thanks .
No problem. I'm doing it now; however, both cables are the same make.
Hooking them both up will slightly change the sound of both cables as all the measurements ... resistance/capacitance and inductance will change. It may get better - it may get worse. You have to try it, as it will not harm anything.
Just be careful you do not short across the outputs by having the spades on the + & - side touch; they tend to slide around a little when you've got 2 on one binding post.