- Should I A-B test different tubes, swapping in/out quickly?
1 - I would not swap tubes quickly especially NEW/NOS because I have found they need a couple of hundred hrs to break in.
Can I mix & match brands, or NOS vs. New etc...?
2 - If you can manually adjust the bias you should be OK BUT I would not mix brands (although it may produce some interesting results). I have found different brands of the same tube types have their own distinct sound.
Should I start from source and move downstream (ph-stage, Line stage,... power amp) or vice versa?
3 - I have an integrated amp so I have no experience here