No, you should not get any damage from connecting either output tap to your speakers, unless, of course, you send a clipped signal to your speakers or overdrive them. Yes, the sound will be different from both taps, especially if your speakers are a difficult load. You may find that bass output, dynamic range, and ultimate loudness may suffer if you connect a 4 ohm speaker to an 8 ohm output tap, but it is difficult to say without knowing the impedance vs frequency curve for your speakers. It is generally best to match the output tap to the speaker load to get the lowest distortion and highest power output.
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