I was hoping to get some responses about the negative or positive aspects of using only 2 22 awg solid wires per channel.
The gauge is inadequate for neutral behavior. AWG 22 wire has a resistance of about 16 ohms per thousand feet. The 24 foot round-trip that the signal has to make, to and from each speaker, corresponds to a resistance of about 0.4 ohms.
That would reduce your damping factor to 8/0.4 = 20, assuming that the damping factor of the amp is high enough to be insignificant in relation to that.
I believe that the impedance of your speakers is nominally 8 ohms but dips to around 4 ohms at some frequencies, especially in the bass region. At those frequencies the effective damping factor would be only 10. Also, the interaction of the 0.4 ohm cable resistance and the variation of speaker impedance as a function of frequency would result in approximately a 0.5 db frequency response irregularity, small but not necessarily insignificant. Finally, depending on the frequency content of the music, between about 10% and 20% of the power delivered by the amplifier at any given time would be wasted, and dissipated in the cables as heat.
See this wire gauge table
for further information on resistance as a function of gauge. For neutral behavior, cable resistance should be kept to an extremely small fraction of the lowest value reached by the impedance of the speaker at any audible frequency.
Although whether or not neutral behavior is the goal, for a given system and listener, is of course another matter altogether.