System synergy or mix and match

I've put together and interesting system....Sonus Faber Cremona Auditor M Stand mounts parred with two REL G-2 subs, Mac 601 monoblocks and Mac C50 pre, Modwright Oppo 105 and Lumin A-1 Streamer with Kenneth Lau PS, all Audience AU24 power chords and high end AQ interconnects and speaker cables.   Thinking of changing to tube line stage and was curious on thoughts out there of sticking with Mac or perhaps trying a different brand.  Seems to be a ton of nice choices out there but I'm also aware of same brand synergy...any input?
Thanks