Suggestions: Best speaker/sub combo for Desktop PC

I'm looking for a solid speaker/sub combo for my desktop and wanted to get some input from you pros out there in cyberspace. I'm not a huge fan of Bose, but I was in a local Bose retail store last night and heard their Companion 5 System ($399) and was highly impressed. Anyone else care to comment on the Bose 5, or any other system in that price range that has good imaging and bass response??? Thanks!

Do you have to have a sub?... that is, will you use this more for music while working, or for watching movies?

For a small, consumer-oriented musical PC speaker, I've found the Klipsch ProMedia 2.0 hard to beat. (approx. $100 retail) They're vented out the back, but still sound a lot cleaner and tighter than any computer speaker costing twice as much at Best Buy or Fry's.

But if you really want to spend $400, you might go to a music equipment store, and check out some of the powered near-field monitors by M-Audio and similar manufacturers.
I actually am a professional musician (orchestral and choral conductor), so music is my life's work and passion, so a sub is important in the equation to get full-range sound...this will not be for casual background listening, but critical imaging. I have a set of LSA 2 speakers that I power with an Arcam SOLO integrated that's what I'm used to hearing...but I'm looking for something that I can use on my PC to approximate full-range sounds when I can't sit in front of my towers....
Clay49, "Classic One" setup with stereo pair, and subwoofer, fits the bill - $529 is not as cheap as Bose,
but when you check out the website,
your more professional/perfectionist need for truly fine miniature speaker computer sound may be better satisfied.
Are you using the computer for playback, and editing, of live digital recordings?
I am using for playback only for score study, and sometimes for pre-editing of recordings my choirs and orchestras have done...I don't do any editing outside of the studio and an SSL Console. I'll check out for the lead....
Chuck Ainlay endorses NHT MOO and SOO...look him up on google. He is a well known sound engineer in Nashville.
You might want to consider some of the TBI products. I have heard their mini monitor and subwoofer combos, and they are great.

I have experience with desktop speaker systems but I am not a pro. Finicky yes. Pro no. Though I spend 70% of my listening time in front of my computer even though I have a very nice system in my living room.

I agree that NHT's Moo and Soo (M00 S00) is a highly regarded system. At the ~$1k it should be sweet sounding - though I have not had the pleasure myself. Other monitor type speakers from genelec, mackie, and JBL should be considered since they are all-in-one (amp and speaker). Just feed the source via RCA or XLR (analog sources only) and you have clean sound. the only thing missing is the preamp and the nicely finished speaker cabinets and grills.

My budget was not at the $1k mark for sound from my Apple G5 in my office. I opted for the Blue sky media desk [ ] which is their entry level monitoring system. I would love to hear the Sky one system.

I have my Media Desk system connected to my apple G5, using iTunes with pure AIFF format source [the same system feeds my "main" audio system]. The relatively small 2.1 system is amazing for nearfield listening (seated at 2-4 ft.) the traditional bass-reflex monitors flank my Cinema Display with the subwoofer at about 5 feet away off of my right shoulder. Blue sky has a philosophy of crossing over their monitors at 110hz to the sub/amp unit, which (to me) is very appropriate for nearfield listening.

The sound is clear and revealing. I hear everything. Old Lightning Slim (blues) recordings are not masked in any way - the rawness is there. Through my very (very) eclectic tastes I have listened to many songs/recordings......And though not a musician, I can hear various types of mic-ing and guitar string types. Do I know the technical names of the strings? No. But they are clearly different. All this is presented by the Media Desks. Also because of this I have found out how poorly some recording truly are (sorry for the bad grammar). This makes sense since these monitors are intended for computer mixing set ups.

So my final suggestion is to consider powered studio monitor type speakers for your computer system. More truth, less flash. There is a wide range of options for all budgets. Note that the distribution of these speakers is different from typical home speakers - instrument dealers/musician supply stores.

I really enjoy listening to the music produced by my Media Desk's! Listening to The Shins currently, but listened to Renata Tebaldi and The Art of Noise earlier.

Let us know what you finally decide upon and why, it'll help others in the same position as yourself. Good luck.

Ed...thanks for your very informative response, I do appreciate your inpute greatly! I'm going to do some investigation into the NHT system. If it works for me, I may even unload my new LSA 2 speakers and ARCAM Solo that I recently bought...I'm all about being more compact now without giving up a lot of sonic quality. I'll post my findings...thanks again!