A great question for Sean or someone else knowledgeable. I hope they answer!
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I have arranged my panel so that loads like the dishwasher are on the leg that is not running the audio. Similiarly the fridge, washer, large motors that kick on by themselves. You have three lines coming to the house- one neutral and two hot. Put the two hots on one circuit and you have 220. Only one hot is 120. So I keep noisy junk on the other leg (other hot). Of course, you are still connected to your neighbors junk.
Of course...but that's not what you asked. Going 240 all the way and then stepping down at the subpanel or going all the way amounts to the same thing. If it's a large house, and the stereo is far away from the main, you go off the subpanel. The only reason to do this is that the resistance is far less through the thick wires going to the sub. If the stereo is near the main, it's better to go straight. Either way, eventually you are connecting to your neighbors trash, so you need the I.T. HOWEVER....what problems does the I.T. cause,if any? Have you A/B'd with and without? What kind are you using?