I use Crescendo III in my system and like them very much. What is the context of your question? Are you considering changing from Crescendo to Crescendo II or trying to decide if the price difference between the two is worth it?
The biggest difference is in the inner core design. My understanding is that the II was an improvement over the original in both dynamics and detail.
The II also supposedly more flexible than the original (it is one seriously thick and stiff cable), but can't imagine that it makes that much of a difference since the III is still like wrestling a boa constrictor sometimes.
The original is a fine cable, but I'd go with the II if given an option.
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