There will be some loss of upper treble, the amount of loss depends on the screen, but usually less than 1dB, just have the speakers as close to the screen as possible.
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I agree that there is some loss of fidelity with using acoustic transparent screen, therefore, not ideal for critical two channel listening. I have two separate setups, home theater with the aforementioned acoustic transparent screen and B&W 804 diamonds behind screen, and a large HTM1 for center, and B&W 15 inch sub behind screen as well. I have a 3 foot deep pocket behind screen which is great for placing speakers behind screen. For the critical two channel setup, which is also on its own dedicated circuits, I optimized the room for stereo listening, vice the typical muted and overdamped with lush wall to wall carpet rooms. Used spot throw rugs, absorbers, diffusion, etc. Home theater is 7.1, 4 in wall speakers, 34x20.
Understandimg that each enthusiast has there own set of issues and compromises, if you can’t go a separate two channel setup, make sure that the speakers are dynamic, and efficient, maybe horns, which offer greater projection authority and perhaps make up for the loss of upper treble and mids which would occur with a screen. I ran separate HDMI, coax, Digitial, XLR, RCA, to my stereo rack in the theater, listening room from the AV rack in another room, to give me further options for connectivity.
By by all means, stereo will still work and can sound great behind a screen, but it will not be fully optimized, especially if you are used to a certain label of fidelity and clarity. Good luck.