Splitting the signal from the dac

Are there any problems with using a multiple splitter for the signal out of a dac, for more than two amps or headphones? Is this similar to running more than two speakers from an amp?
Not quite the same since we are concerned with voltage, not power, here. The answer depends on the output impedance of the DAC and the input impedances of the two loads.

Why not use the additional output from the preamp, assuming you are feeding into one?: DAC into preamp, and send the various pre outputs (you can get an RCA splitter if you only have a single output) to your various amps. In that case there would be no problem at all.