Not really sure about what you are asking. Kind of obvious if the amp does not mate with the speakers, example 20 watt amp on a pair of 3.7 magneplanars or an amp that is not stable at 2 ohms with electrostatics, your dead in the water. Cabling is irrelavant if you cant power up the speakers correctly. So if all things are equal right amp with speakers the correct cabling is an obvious concern. Question is very general one could go in any direction. One could answer yes or no to your question and be correct. We need a little more meat on the bones to give you a better answer.
