Speaker placement after component changes?

I just tried the Sumiko Master Set method and the results are pretty damn amazing, but I did it with a temporary amp and pre while my main amp is in the shop. Will I have to redo this once I get it back because it has a different sound? What about cable, source, and any other changes? That would be a pain the arse, especially if you're rolling tubes!
I don't use the Sumiko, but I did need to move my speakers away from the walls a little after I got new tubes. The JJ 2A3-40 tubes I have now put out a good bit more bass than the tubes I had before, so I needed to reposition.
Not uncommon to have to tweak speaker location somewhat for best results after an equipment change of any type.