Sure. Use 12 gauge OFC cables. The cost should be about 50 cents a foot...
My system is a SET powered amp (Art Audio PX-25) going to highly modified Klipsch horns ( thanks to Morray James suggestions). After trying many different cables I am using a full compliment of Synergistic Research cables. The improved openness and reduced background noise is wonderfull.
I'm not sure I think cables would be speaker dependant, but I have gone through a few different ones recently. I replaced Kimber 8TC with Tellerium Q Black and felt like I had improved everything. I noticed getting better lyrics from songs. I needed to go from ten feet to more than twenty and the price was considerable! I discovered River Cables, and bought their best, seven gage, flat and wide. I have been delighted with the performance, better than either of the previous ones, and cheaper. They seem so neutral, and locking bananas are a bonus. At least give their site a look, but if you want theTellerium Black,write back:)