hi, with mine i keep them from running parallel to other cables, elevated from the floor and try to keep them isolated from vibration as much as possible.
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I agree exactly with both above responses. Also keep in mind prepping all contact surfaces including the speaker spades/bananas/pins, as well as the speaker and amp binding posts (not to mention all your system connections). I find Caig deoxit and Pro gold excellent for this. You might also like to get yourself a binding post wrench (Audioquest makes a good one) for securely connecting the cables (better than bare hands, easier/safer than "real" wrenches or pliers).
I also found it's best not to disturb all your cables (incl I/C's ,PS's, speaker cables), once you've placed them, don't move them after that. Good luck
The only way to insure your cables are not exposed to vibration is to not use the speakers. Otherwise, as long as all your other cables are sufficiently shielded it simply makes sense to keep AC and speaker wires away from signal cables, with the speaker wire visable so you can look at how pretty it is. Keeping speaker wire off the floor can be useful when vacuuming the dust under it. Or run the speaker wire through a hole in the floor suspended in the basement ceiling (or lower floor) air...this is very useful for hanging laundry or drying plants from it as long as your laundry or drying plants don't vibrate.
I'm here for "my people" as but a humble servant. I've noticed some recent ads in high end mags showing speakers in glamorous spaces near gigantic windows with diaphonous curtains and a sultry female...NO speaker wire at all. I guess if your house is that cool you just put the speakers over there hooked up to nothing so you can look at 'em and not be bothered with sound while gazing out at the pool with the aforementioned ad babe. Obviates the wire issue.