Speaker cable geometry question

First of all, I'm sure this has been asked somewhere but I couldn't find it.  I have been out of the loop for a while and have just gotten back into the hobby and am looking for an answer on this (because I am just curious).  
Most speaker cables consist of any number of geometries in a single run from amp to each speaker in a single sheath.    Some however have single runs of + and - to each speaker.  Such examples include certain Purist cables such as Dominus and Neptune, Jena Labs and Nordost.  I am sure there are more but these are the ones that came to mind.
What is the advantage or disadvantage of doing a cable run in this manner.  These are very expensive brands and I've been rekindling my interest and this is one area in which I have developed a particular curiosity.