I say yes. I have a G4 with a RME soundcard. I don't believe the CPU is particularly important in that the playback of digital audio files is a fairly low load processor task. The RME has both S/PID and AES/EBU digital outputs which are attached to an external DAC. As such the G4 is acting as a CD transport and while I haven't done any direct comparisons with high cost transports, I haven't noticed any deterioration in sound quality when compared to the Sony 333ES when used as a transport. If you don't want to use an external DAC, then you might want to look at the Lynx soundcards. They have an excellent reputation for sound quality.
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