This is what an Aussie, Neville Thiel (RIP) of the Thiel & Small parameters, that all driver/box are calculated on once told me, and it works a treat.
To try to cancel any bass standing wave problems, odd ratio measurements should be applied, never even ratios.
Best: the third rule to the bass driver should be applied, and if that is not practical then 2nd best do fifths, 3rd best is 7th's
So for 3rds in a 22' x 16' = 7.3' from the back wall and 5.3' from the side wall
For fifth's = 4.4' from the back wall and 3.2' from the side wall
Or you can use a combination of 1/3's and 1/5s'
You can't do much about the floor ceiling measurement, and your toe-in is up to you, I like the tweeters crossing over just behind my head.