Small Speakers For A Large Room...

I'm about to move my system into a much larger room - ~4,000 cu feet - but for domestic tranquility (I love my wife far more than my music) will need to keep the speakers on the small side. What options are out there in a large stand mount or slender floor standing speaker that work well in large room? I don't listen very loud, and will have a separate powered subwoofer, but mains that visually dominate the room are not an option for me.

If you know of small-ish speakers that sound large, I'd appreciate some suggestions!
One of the things to consider in a large room is, unless you listen nearfield, most of the sound that reaches your ears will be reverberant sound. So the speaker's off-axis performance will play a larger role in the perceived tonal balance than you're probably used to.

Unfortunately, most small speakers are designed to be listened to up close, like in a small room, so the designer probably paid more attention to the on-axis sound than to what's happening off-axis. But if the radiation pattern is fairly uniform (doesn't have major off-axis flares and valleys), that's bodes well for good sound in a large room.

Another potential issue is maintaining good dynamic contrast. Speakers have to play louder to do a decent job of filling a large room, and as they play louder their voice coils heat up, and that in turn causes thermal compression which reduces their dynamic contrast. For a high fidelity application, I like to have speakers that can hit the anticipated peaks at about 1/10th their rated long-term power handling. That gets harder to do with small speakers, which typically have more modest power handling to begin with, and then trade off efficiency for bass extension.

Your secret weapon here is your decision early on to use subwoofers. This frees you up to seek out satellite speakers that may only go down to 80 Hz or so, but they will generally be higher efficiency than same-size speakers that go down deeper. Of course you don't "need" as much headroom as I described above, but imo good dynamic contrast contributes a lot to the experience. So don't seek out satellites that have a lot of bass extension you don't need, because you'll be paying a penalty in efficiency - and thus most likely in dynamic contrast - for that surplus low end.

You might consider Silverline SR17 Supreme. I have used it in a large room with a sub with great success. It uses the Dynaudio Esotar tweeter.
I'd also suggest the Tekton m-Lores (34" x 9" x 10"). I purchased a pair for use as surround speakers, but have been toying around with them as my main speakers in a 35' x 15' x 8' loft (4200 sq feet) and have been pleasantly surprised how easily they fill the room. Very musical, big sound, surprising bass, and they sound very good on all types of music. They are not the last word on extracting all the details of the music, so be aware of that if you are a detail freak. The are easy to drive and not fussy about placement.
Post removed 
Another vote for Joseph Audio Pulsars. Nice looking speakers that I'd think have a high WAF and play big for their size, especially since you'll be running a sub with them. Also, to Audiokinesis' point, I believe they have very good dispersion characteristics.

By the way, the fact that you love your wife much more than your music tells me you're either a newlywed or sorely in need of better music. Either way, best of luck.